MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes
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چکیده
منابع مشابه
Organizing MHC Class II Presentation
Major histocompatibility complex (MHC) class II molecules are ligands for CD4(+) T cells and are critical for initiating the adaptive immune response. This review is focused on what is currently known about MHC class II organization at the plasma membrane of antigen presenting cells and how this affects antigen presentation to T cells. The organization and diffusion of class II molecules have b...
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Antigen presentation is highly critical in adoptive immunity. Only by interacting with antigens presented by major histocompatibility complex class II molecules, helper T cells can be stimulated to fight infections or diseases. The degradation of a full protein into small peptide fragments bound to class II molecules is a dynamic, lengthy process consisting of many steps and chaperons. Deregula...
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ژورنال
عنوان ژورنال: Experimental and Molecular Pathology
سال: 2008
ISSN: 0014-4800
DOI: 10.1016/j.yexmp.2008.03.011